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FKHRL1 (Phospho Ser315) Rabbit Polyclonal Antibody

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产品基本信息

产品货号
BD-PP1586
产品名称
FKHRL1 (Phospho Ser315) Rabbit Polyclonal Antibody
别名
Forkhead box protein O3 (AF6q21 protein;Forkhead in rhabdomyosarcoma-like 1)
类别
常规抗体
基因名称
FOXO3 FKHRL1 FOXO3A
蛋白名称
FKHRL1 (Phospho Ser315)
推荐应用
WB
反应种属
Human,Mouse,Rat
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
2309
Human Gene Link
https://www.uniprot.org/uniprot/2309
Human Swissprot No.
O43524
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O43524/entry
Mouse Gene ID
56484
Mouse Gene Link
https://www.uniprot.org/uniprot/56484
Mouse Swissprot No.
Q9WVH4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9WVH4
免疫原
Synthesized peptide derived from human FKHRL1 (Phospho Ser315)
特异性
This antibody detects endogenous levels of Human,Mouse,Rat FKHRL1 (Phospho Ser315)
稀释度
WB 1:1000-2000 ELISA 1:5000-20000
预测分子量
71kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
disease:A chromosomal aberration involving FOXO3 is found in secondary acute leukemias. Translocation t(6;11)(q21;q23) with MLL/HRX.,function:Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'.,PTM:In the presence of survival factors such as IGF-1, phosphorylated on Thr-32 and Ser-253 by AKT1/PKB. This phosphorylated form then interacts with 14-3-3 proteins and is retained in the cytoplasm. Survival factor withdrawal induces dephosphorylation and promotes translocation to the nucleus where the dephosphorylated protein induces transcription of target genes and triggers apoptosis. Although AKT1/PKB doesn't appear to phosphorylate Ser-315 directly, it may activate other kinases that trigger phosphorylation at this residue. Phosphorylated by STK4 on Ser-209 upon oxidative stress, which leads to dissociation from YWHAB/14-3-3-beta and nuclear translocation.,similarity:Contains 1 fork-head DNA-binding domain.,subcellular location:Translocates to the nucleus upon oxidative stress and in the absence of survival factors.,subunit:Interacts with YWHAB/14-3-3-beta and YWHAZ/14-3-3-zeta, which are required for cytosolic sequestration. Upon oxidative stress, interacts with STK4, which disrupts interaction with YWHAB/14-3-3-beta and leads to nuclear translocation.,tissue specificity:Ubiquitous.,
组织表达
Ubiquitous.
细胞定位
Cytoplasm, cytosol . Nucleus . Mitochondrion matrix . Mitochondrion outer membrane ; Peripheral membrane protein ; Cytoplasmic side . Retention in the cytoplasm contributes to its inactivation (PubMed:10102273, PubMed:15084260, PubMed:16751106). Translocates to the nucleus upon oxidative stress and in the absence of survival factors (PubMed:10102273, PubMed:16751106). Translocates from the cytosol to the nucleus following dephosphorylation in response to autophagy-inducing stimuli (By similarity). Translocates in a AMPK-dependent manner into the mitochondrion in response to metabolic stress (PubMed:23283301, PubMed:29445193). Serum deprivation increases localization to the nucleus, leading to activate expression of SOX9 and subsequent chondrogenesis (By similarity). .
功能
ovarian follicle development,?ovulation from ovarian follicle,?initiation of primordial ovarian follicle growth,?antral ovarian follicle growth,?oocyte maturation,?reproductive developmental process,?transcription,?regulation of transcription, DNA-dependent,?regulation of transcription from RNA polymerase II promoter,?apoptosis,?induction of apoptosis,?response to DNA damage stimulus,?gamete generation,?germ cell development,?female gamete generation,?sex differentiation,cell death,?gonad development,?female gonad development,?positive regulation of biosynthetic process,?oocyte differentiation,?positive regulation of macromolecule biosynthetic process,?positive regulation of macromolecule metabolic process,?positive regulation of gene expression,?regulation of cell death,?positive regulation of cell death,programmed cell death,?induction of programmed cell death,?death,?sexual reproduction,?developmental maturation,ovulation cycle process,?ovulation,?positive regulation of cellular biosynthetic process,?multicellular organism reproduction,?regulation of homeostatic process,?carbohydrate homeostasis,?cellular response to stress,?growth,homeostatic process,?glucose homeostasis,?ovulation cycle,?regulation of apoptosis,?positive regulation of apoptosis,regulation of programmed cell death,?positive regulation of programmed cell death,?development of primary sexual characteristics,?regulation of transcription,?positive regulation of cell differentiation,?regulation of myeloid cell differentiation,?positive regulation of myeloid cell differentiation,?regulation of erythrocyte differentiation,?positive regulation of erythrocyte differentiation,?positive regulation of transcription, DNA-dependent,?positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process,?positive regulation of transcription,?positive regulation of transcription from RNA polymerase II promoter,?development of primary female sexual characteristics,female sex differentiation,?cell maturation,?oogenesis,?rhythmic process,?developmental growth,?oocyte development,reproductive structure development,?reproductive process in a multicellular organism,?reproductive cellular process,chemical homeostasis,?positive regulation of developmental process,?positive regulation of nitrogen compound metabolic process,?regulation of RNA metabolic process,?positive regulation of RNA metabolic process,
期货
现货
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

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