产品名称
PSF2 Rabbit Polyclonal Antibody
基因名称
GINS2 PSF2 CGI-122 DC5 HSPC037
蛋白名称
DNA replication complex GINS protein PSF2 (GINS complex subunit 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9Y248
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y248/entry
Mouse Swissprot No.
Q9D600
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9D600
免疫原
Synthesized peptide derived from part region of human protein
特异性
PSF2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1 (GINS1; MIM 610608), Psf2, and Psf3 (GINS3; MIM 610610). The formation of this complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.[supplied by OMIM, Mar 2008],
组织表达
Brain,Dendritic cell,Umbilical cord blood,
细胞定位
Nucleus . Chromosome . Associates with chromatin. .
功能
function:The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.,mass spectrometry:This is the measured mass for the GINS complex PubMed:17557111,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the GINS2/PSF2 family.,subunit:Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS3. GINS complex interacts with DNA primase in vitro.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
