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Smad1 (Phospho Ser214) Rabbit Polyclonal Antibody

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产品基本信息

产品货号
BD-PP1577
产品名称
Smad1 (Phospho Ser214) Rabbit Polyclonal Antibody
别名
Mothers against decapentaplegic homolog 1 (MAD homolog 1;Mothers against DPP homolog 1;JV4-1;Mad-related protein 1;SMAD family member 1;SMAD 1;Smad1;hSMAD1;Transforming growth factor-beta-signaling protein 1;BSP-1)
类别
常规抗体
基因名称
SMAD1 BSP1 MADH1 MADR1
蛋白名称
Smad1 (Phospho Ser214)
推荐应用
WB
反应种属
Human,Mouse,Rat
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
4086
Human Gene Link
https://www.uniprot.org/uniprot/4086
Human Swissprot No.
Q15797
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q15797/entry
Mouse Gene ID
17125
Mouse Gene Link
https://www.uniprot.org/uniprot/17125
Mouse Swissprot No.
P70340
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P70340
Rat Swissprot No.
P97588
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P97588
免疫原
Synthesized peptide derived from human Smad1 (Phospho Ser214)
特异性
This antibody detects endogenous levels of Human,Mouse,Rat Smad1 (Phospho Ser214)
稀释度
WB 1:500-2000;IHC-p 1:50-300
预测分子量
51kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
function:Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD).,PTM:Phosphorylated on serine by BMP type 1 receptor kinase.,PTM:Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1.,similarity:Belongs to the dwarfin/SMAD family.,similarity:Contains 1 MH1 (MAD homology 1) domain.,similarity:Contains 1 MH2 (MAD homology 2) domain.,subcellular location:Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.,subunit:Interacts with HGS, NANOG and ZCCHC12 (By similarity). May form trimers with another SMAD1 and the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit, CREB-binding protein (CBP), p300, SMURF1, SMURF2 and HOXC8. Associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes. Interacts with LBXCOR1.,tissue specificity:Ubiquitous. Highest expression seen in the heart and skeletal muscle.,
组织表达
Ubiquitous. Highest expression seen in the heart and skeletal muscle.
细胞定位
Cytoplasm . Nucleus . Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4 (PubMed:15647271). Co-localizes with LEMD3 at the nucleus inner membrane (PubMed:15647271). Exported from the nucleus to the cytoplasm when dephosphorylated (By similarity). .
功能
MAPKKK cascade,?skeletal system development,?ossification,?osteoblast differentiation,?urogenital system development,?formation of primary germ layer,?mesoderm formation,?mesodermal cell fate commitment,?kidney development,?osteoblast fate commitment,?transcription,?regulation of transcription, DNA-dependent,?regulation of transcription from RNA polymerase II promoter,?RNA processing,?protein complex assembly,?defense response,inflammatory response,?cell surface receptor linked signal transduction,?enzyme linked receptor protein signaling pathway,?transmembrane receptor protein serine/threonine kinase signaling pathway,?transforming growth factor beta receptor signaling pathway,?SMAD protein complex assembly,?intracellular signaling cascade,?protein kinase cascade,?gamete generation,?gastrulation,?pattern specification process,?mesoderm development,?negative regulation of cell proliferation,?response to wounding,?response to endogenous stimulus,?embryonic pattern specification,positive regulation of biosynthetic process,?response to organic substance,?response to organic nitrogen,?positive regulation of macromolecule biosynthetic process,?positive regulation of macromolecule metabolic process,?negative regulation of macromolecule metabolic process,?posttranscriptional regulation of gene expression,?positive regulation of gene expression,?negative regulation of gene expression,?positive regulation of cell development,?regulation of cell morphogenesis involved in differentiation,?regulation of neuron projection development,?posttranscriptional gene silencing,?gene silencing,?sexual reproduction,?regulation of cell morphogenesis,?regulation of ossification,?BMP signaling pathway,?midbrain development,?hindbrain development,?gene silencing by RNA,?dsRNA fragmentation,primary microRNA processing,?positive regulation of cellular biosynthetic process,?regulation of cell projection organization,?positive regulation of cell projection organization,?multicellular organism reproduction,?ncRNA processing,cellular macromolecular complex subunit organization,?cellular macromolecular complex assembly,?posttranscriptional gene silencing by RNA,?gene silencing by miRNA,?gene silencing by miRNA, production of miRNAs,?regulation of gene expression, epigenetic,?wound healing,?regulation of cell proliferation,?response to drug,?homeostatic process,response to dsRNA,?cellular protein complex assembly,?macromolecular complex subunit organization,?cell fate commitment,?regulation of transcription,?positive regulation of cell differentiation,?regulation of neuron differentiation,regulation of osteoblast differentiation,?positive regulation of osteoblast differentiation,?regulation of anti-apoptosis,positive regulation of anti-apoptosis,?positive regulation of transcription, DNA-dependent,?positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process,?positive regulation of transcription,?positive regulation of transcription from RNA polymerase II promoter,?mesoderm morphogenesis,?mesodermal cell differentiation,?embryonic morphogenesis,?reproductive process in a multicellular organism,?tissue morphogenesis,regulation of dendrite morphogenesis,?regulation of neurogenesis,?positive regulation of neurogenesis,?regulation of dendrite development,?positive regulation of dendrite morphogenesis,?positive regulation of developmental process,positive regulation of cellular component organization,?positive regulation of nitrogen compound metabolic process,regulation of RNA metabolic process,?positive regulation of RNA metabolic process,?regulation of nervous system development,?regulation of cell development,?bone development,?macromolecular complex assembly,?protein complex biogenesis,
期货
现货
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

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