产品名称
MAX (Phospho Ser11) Rabbit Polyclonal Antibody
别名
Protein max (Class D basic helix-loop-helix protein 4;bHLHd4;Myc-associated factor X)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/4149
Human Swissprot No.
P61244
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P61244/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/0
Mouse Swissprot No.
P28574
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P28574
Rat Gene Link
https://www.uniprot.org/uniprot/60661
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P52164
免疫原
Synthesized peptide derived from human MAX (Phospho Ser11)
特异性
This antibody detects endogenous levels of Human,Mouse,Rat MAX (Phospho Ser11)
稀释度
WB 1:1000-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012],
组织表达
High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.
细胞定位
Nucleus. Cell projection, dendrite .
功能
alternative products:Additional isoforms seem to exist,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3-K9 histone methyltransferase activity.,PTM:Reversible lysine acetylation might regulate the nuclear-cytoplasmic shuttling of specific Max complexes.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MYC or MAD. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Interacts with SPAG9.,tissue specificity:High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
