产品名称
PSF1 Rabbit Polyclonal Antibody
蛋白名称
DNA replication complex GINS protein PSF1 (GINS complex subunit 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q14691
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q14691/entry
Mouse Swissprot No.
Q9CZ15
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9CZ15
免疫原
Synthesized peptide derived from part region of human protein
特异性
PSF1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1, Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]).[supplied by OMIM, Mar 2008],
细胞定位
Nucleus . Chromosome . Associates with chromatin. .
功能
function:The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA. GINS1 is essential for function.,induction:Significantly up-regulated in agressive melanomas.,mass spectrometry:This is the measured mass for the GINS complex PubMed:17557111,similarity:Belongs to the GINS1/PSF1 family.,subunit:Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
