产品名称
CTIP (Phospho Ser327) Rabbit Polyclonal Antibody
别名
DNA endonuclease RBBP8 (EC 3.1.-.-;CtBP-interacting protein;CtIP;Retinoblastoma-binding protein 8;RBBP-8;Retinoblastoma-interacting protein and myosin-like;RIM;Sporulation in the absence of SPO11 protein 2 homolog;SAE2)
蛋白名称
CTIP (Phospho Ser327)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/5932
Human Swissprot No.
Q99708
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q99708/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/225182
Mouse Swissprot No.
Q80YR6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q80YR6
Rat Gene Link
https://www.uniprot.org/uniprot/291787
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/B1WC58
免疫原
Synthesized peptide derived from human CTIP (Phospho Ser327)
特异性
This antibody detects endogenous levels of Human,Mouse CTIP (Phospho Ser327)
稀释度
WB 1:1000-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008],
组织表达
Expressed in ER-positive breast cancer lines, but tends to be down-regulated ER-negative cells (at protein level).
细胞定位
Nucleus . Chromosome . Associates with sites of DNA damage in S/G2 phase (PubMed:10764811, PubMed:25349192). Ubiquitinated RBBP8 binds to chromatin following DNA damage (PubMed:16818604). .
功能
function:May modulate the functions ascribed to BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR. Hyperphosphorylation upon ionizing radiation results in dissociation from BRCA1.,PTM:Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.,subcellular location:Predominantly nuclear.,subunit:Interacts with CTBP, with the C-terminal (BRCT) domains of BRCA1, and with the retinoblastoma protein.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
