产品名称
DPOD4 Rabbit Polyclonal Antibody
蛋白名称
DNA polymerase delta subunit 4 (DNA polymerase delta subunit p12)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9HCU8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9HCU8/entry
Mouse Swissprot No.
Q9CWP8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9CWP8
免疫原
Synthesized peptide derived from part region of human protein AA range: 1-50
特异性
DPOD4 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes the smallest subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein enhances the activity of DNA polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012],
组织表达
Brain,Cervix,Ovarian carcinoma,Pooled,
细胞定位
Nucleus . Partially recruited to DNA damage sites within 2 hours following UV irradiation, before degradation. .
信号通路
Purine metabolism;Pyrimidine metabolism;DNA replication;Base excision repair;Nucleotide excision repair;Mismatch repair;Homologous recombination;
功能
function:Required for optimal DNA polymerase delta activity. May contribute to PCNA-dependent activity of DNA polymerase delta.,similarity:Belongs to the DNA polymerase delta subunit 4 family.,subunit:Heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. Interacts with WRNIP1. Interacts with POLD4, POLD2, POLD1 and PCNA.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
