产品名称
CTIP (Phospho Ser327) Rabbit Polyclonal Antibody
别名
DNA endonuclease RBBP8 (EC 3.1.-.-;CtBP-interacting protein;CtIP;Retinoblastoma-binding protein 8;RBBP-8;Retinoblastoma-interacting protein and myosin-like;RIM;Sporulation in the absence of SPO11 protein 2 homolog;SAE2)
蛋白名称
CTIP (Phospho Ser327)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/5932
Human Swissprot No.
Q99708
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q99708/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/225182
Mouse Swissprot No.
Q80YR6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q80YR6
Rat Gene Link
https://www.uniprot.org/uniprot/291787
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/B1WC58
免疫原
Synthesized peptide derived from human CTIP (Phospho Ser327)
特异性
This antibody detects endogenous levels of Human,Mouse CTIP (Phospho Ser327)
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008],
组织表达
Expressed in ER-positive breast cancer lines, but tends to be down-regulated ER-negative cells (at protein level).
细胞定位
Nucleus . Chromosome . Associates with sites of DNA damage in S/G2 phase (PubMed:10764811, PubMed:25349192). Ubiquitinated RBBP8 binds to chromatin following DNA damage (PubMed:16818604). .
功能
function:May modulate the functions ascribed to BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR. Hyperphosphorylation upon ionizing radiation results in dissociation from BRCA1.,PTM:Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.,subcellular location:Predominantly nuclear.,subunit:Interacts with CTBP, with the C-terminal (BRCT) domains of BRCA1, and with the retinoblastoma protein.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
