产品名称
SMC6 Rabbit Polyclonal Antibody
蛋白名称
Structural maintenance of chromosomes protein 6 (SMC protein 6) (SMC-6) (hSMC6)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/79677
Human Swissprot No.
Q96SB8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96SB8/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/67241
Mouse Swissprot No.
Q924W5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q924W5
Rat Gene Link
https://www.uniprot.org/uniprot/67241
免疫原
Synthesized peptide derived from human SMC6 AA range: 719-769
特异性
This antibody detects endogenous levels of human SMC6
宿主
Polyclonal, Rabbit,IgG
组织表达
Widely expressed (PubMed:11408570). Strongly expressed in testis (PubMed:11408570).
细胞定位
Nucleus . Nucleus speckle . Chromosome . Nucleus, PML body . Chromosome, telomere . Colocalizes with SMC5 on the X-Y chromosome pair within the sex vesicle during late pachytene/diplotene (By similarity). Localizes to PML nuclear bodies in ALT cell lines (PubMed:17589526). Associates with chromatin (PubMed:25931565). Accumulates with RAD18 and the SLF1-SLF2 complex at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565). Localizes in interchromatin granule clusters (PubMed:11408570). .
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
