产品名称
ABC3H Rabbit Polyclonal Antibody
蛋白名称
DNA dC->dU-editing enzyme APOBEC-3H (EC 3.5.4.-) (APOBEC-related protein 10) (ARP-10) (Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3H)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q6NTF7
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q6NTF7/entry
免疫原
Synthesized peptide derived from part region of human protein
特异性
ABC3H Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3 family of proteins. The encoded protein is a cytidine deaminase that has antiretroviral activity by generating lethal hypermutations in viral genomes. Polymorphisms and alternative splicing in this gene influence its antiretroviral activity and are associated with increased resistence to human immunodeficiency virus type 1 infection in certain populations. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009],
组织表达
Expressed in lymphoid organs. Also detected in non-lymphoid tissues including lung, testis, ovary, fetal liver and skin.
细胞定位
Nucleus. Cytoplasm. Cytoplasm, P-body. Haplotype 1 is distributed in both the nucleus and cytoplasm, whereas haplotype 2 is predominantly cytoplasmic.
功能
cofactor:Zinc.,function:Poorly expressed deaminase that is ineffective at inhibiting retroviral replication. Has DNA deaminase (cytidine deaminase) activity but is not able to mediate G-to-A hypermutation in newly synthesized retroviral DNA.,miscellaneous:APOBEC3H from old world monkeys has retained its antiviral activity, while it is lost in other primates.,miscellaneous:It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22.,similarity:Belongs to the cytidine and deoxycytidylate deaminase family.,tissue specificity:Present at low level in 293T cells. Unstable protein, suggesting that it may be degraded by the proteasome (at protein level). Weakly expressed. Expressed in testis, ovary, fetal liver and skin.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
