BD-PN0643

DLG3 Rabbit Polyclonal Antibody

常规抗体

DLG3 KIAA1232

Disks large homolog 3 (Neuroendocrine-DLG) (Synapse-associated protein 102) (SAP-102) (SAP102) (XLMR)

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

1741

Q92796

https://www.uniprot.org/uniprotkb/Q92796/entry

P70175

http://www.uniprot.org/uniprot/P70175

Q62936

http://www.uniprot.org/uniprot/O54941Q62936

Synthesized peptide derived from part region of human protein

DLG3 Polyclonal Antibody detects endogenous levels of protein.

WB 1:500-2000 ELISA 1:5000-20000

89kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked mental retardation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009],

Brain,Fetal brain,Thymus,Trachea,

extracellular space,cytoplasm,plasma membrane,bicellular tight junction,ionotropic glutamate receptor complex,postsynaptic density,basolateral plasma membrane,growth cone,AMPA glutamate receptor complex,neuronal cell body,d

alternative products:Named isoforms=2,disease:Defects in DLG3 are the cause of mental retardation X-linked type 90 (MRX90) [MIM:300189]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.,function:Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.,similarity:Belongs to the MAGUK family.,similarity:Contains 1 guanylate kinase-like domain.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 3 PDZ (DHR) domains.,subunit:Interacts through its PDZ domains with GRIN2B and SYNGAP1. Interacts through its guanylate kinase-like domain with DLGAP1, DLGAP2, DLGAP3 and DLGAP4 (By similarity). Interacts through its PDZ domains with APC. Interacts through its first two PDZ domains with ERBB4. Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.