产品名称
MEFV Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/4210
Human Swissprot No.
O15553
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O15553/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/54483
Mouse Swissprot No.
Q9JJ26
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JJ26
Rat Gene Link
https://www.uniprot.org/uniprot/54483
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JJ25
免疫原
Synthesized peptide derived from human MEFV AA range: 517-567
特异性
This antibody detects endogenous levels of human MEFV
宿主
Polyclonal, Rabbit,IgG
组织表达
Expressed in peripheral blood leukocytes, particularly in mature granulocytes and to a lesser extent in monocytes but not in lymphocytes. Detected in spleen, lung and muscle, probably as a result of leukocyte infiltration in these tissues. Not expressed in thymus, prostate, testis, ovary, small intestine, colon, heart, brain, placenta, liver, kidney, pancreas. Expression detected in several myeloid leukemic, colon cancer, and prostate cancer cell lines.
细胞定位
[Isoform 1]: Cytoplasm, cytoskeleton . Cell projection, ruffle . Cell projection, lamellipodium . Nucleus . Cytoplasm . Cytoplasmic vesicle, autophagosome . Associated with microtubules and with the filamentous actin of perinuclear filaments and peripheral lamellar ruffles (PubMed:11468188). In pre-apoptotic cells, colocalizes with PYCARD/ASC in large specks (inflammasomes) (PubMed:11468188). In migrating monocytes, strongly polarized at the leading edge of the cell where it colocalizes with polymerizing actin and PYCARD/ASC (PubMed:11468188). .; [Isoform 2]: Nucleus .
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
