产品名称
PSF2 Rabbit Polyclonal Antibody
基因名称
GINS2 PSF2 CGI-122 DC5 HSPC037
蛋白名称
DNA replication complex GINS protein PSF2 (GINS complex subunit 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9Y248
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y248/entry
Mouse Swissprot No.
Q9D600
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9D600
免疫原
Synthesized peptide derived from part region of human protein
特异性
PSF2 Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1 (GINS1; MIM 610608), Psf2, and Psf3 (GINS3; MIM 610610). The formation of this complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.[supplied by OMIM, Mar 2008],
组织表达
Brain,Dendritic cell,Umbilical cord blood,
细胞定位
Nucleus . Chromosome . Associates with chromatin. .
功能
function:The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.,mass spectrometry:This is the measured mass for the GINS complex PubMed:17557111,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the GINS2/PSF2 family.,subunit:Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS3. GINS complex interacts with DNA primase in vitro.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
