产品名称
PSF1 Rabbit Polyclonal Antibody
蛋白名称
DNA replication complex GINS protein PSF1 (GINS complex subunit 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q14691
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q14691/entry
Mouse Swissprot No.
Q9CZ15
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9CZ15
免疫原
Synthesized peptide derived from part region of human protein
特异性
PSF1 Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1, Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]).[supplied by OMIM, Mar 2008],
细胞定位
Nucleus . Chromosome . Associates with chromatin. .
功能
function:The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA. GINS1 is essential for function.,induction:Significantly up-regulated in agressive melanomas.,mass spectrometry:This is the measured mass for the GINS complex PubMed:17557111,similarity:Belongs to the GINS1/PSF1 family.,subunit:Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
