产品名称
PI4KA Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/5297
Human Swissprot No.
P42356
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P42356/entry
免疫原
Synthesized peptide derived from human PI4KA AA range: 1065-1115
特异性
This antibody detects endogenous levels of PI4KA at Human
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. [provided by RefSeq, Sep 2014],
组织表达
Expressed ubiquitously. Highest levels in placenta and brain. Little or no expression in lung, liver, pancreas, testis or leukocytes.
细胞定位
Cytoplasm . Cell membrane . Localization to the plasma membrane is mediated by the PI4K complex and association with EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and FAM126 (FAM126A or FAM126B) (PubMed:23229899). Localization to the plasma membrane is regulated by TMEM150A (PubMed:25608530). .
功能
catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.,enzyme regulation:This is a type II PtdIns-4-kinase activated by detergents such as triton and inhibited by adenosine.,function:Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate.,similarity:Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.,similarity:Contains 1 PI3K/PI4K domain.,tissue specificity:Expressed ubiquitously. Highest levels in placenta and brain. Little or no expression in lung, liver, pancreas, testis or leukocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
