产品名称
DC1I2 Rabbit Polyclonal Antibody
基因名称
DYNC1I2 DNCI2 DNCIC2
蛋白名称
Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q13409
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q13409/entry
Mouse Swissprot No.
O88487
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O88487
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q62871
免疫原
Synthesized peptide derived from part region of human protein
特异性
DC1I2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the dynein intermediate chain family. The encoded protein is a non-catalytic component of the cytoplasmic dynein 1 complex, which acts as a retrograde microtubule motor to transport organelles and vesicles. A pseudogene of this gene is located on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012],
组织表达
Brain,Cajal-Retzius cell,Endometrium,Epithelium,Kidney,Skin
细胞定位
Cytoplasm, cytoskeleton . Cytoplasm . Detected in the cytoplasm of pachytene spermatocytes. Localizes to the manchette in elongating spermatids. .
功能
function:The intermediate chains seem to help dynein bind to dynactin 150 kDa component.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Unlikely isoform. Several sequence problems.,similarity:Belongs to the dynein intermediate chain family.,similarity:Contains 7 WD repeats.,subunit:Consists of at least two heavy chains and a number of intermediate and light chains.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
