产品名称
CGL Rabbit Polyclonal Antibody
蛋白名称
Cystathionine gamma-lyase (EC 4.4.1.1) (Cysteine-protein sulfhydrase) (Gamma-cystathionase)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P32929
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P32929/entry
Mouse Swissprot No.
Q8VCN5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8VCN5
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P18757
免疫原
Synthesized peptide derived from part region of human protein
特异性
CGL Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010],
组织表达
Highly expressed in liver (PubMed:10727430, PubMed:20305127). Also in muscle and lower expression in most tissues except heart, pituitary gland, spleen, thymus, and vascular tissue, where it is hardly detected (PubMed:20305127).
信号通路
Glycine; serine and threonine metabolism;Cysteine and methionine metabolism;Selenoamino acid metabolism;Nitrogen metabolism;
功能
catalytic activity:L-cystathionine + H(2)O = L-cysteine + NH(3) + 2-oxobutanoate.,cofactor:Pyridoxal phosphate.,disease:Defects in CTH are the cause of cystathioninuria [MIM:219500]. CTH is an autosomal recessive phenotype characterized by abnormal accumulation of plasma cystathionine, leading to increased urinary excretion.,pathway:Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the trans-sulfuration enzymes family.,subunit:Homotetramer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
