产品名称
C1QA Rabbit Polyclonal Antibody
蛋白名称
Complement C1q subcomponent subunit A
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P02745
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P02745/entry
Mouse Swissprot No.
P98086
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P98086
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P31720
免疫原
Synthesized peptide derived from part region of human protein AA range: 181-230
特异性
C1QA Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 IHC-p 1:50-200 ELISA 1:5000-20000. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the A-chain polypeptide of human complement subcomponent C1q. [provided by RefSeq, Jul 2008],
组织表达
Liver,Monocyte,Plasma,Spleen,
信号通路
Complement and coagulation cascades;Prion diseases;Systemic lupus erythematosus;
功能
disease:Defects in C1QA are a cause of C1q deficiency [MIM:120550]. It is a rare genetic disorder which is associated with recurrent infections and a high prevalence of lupus erythematosus-like symptoms. It is characterized by a loss of activation of the complement classical pathway.,function:C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.,online information:C1QA mutation db,PTM:O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups.,similarity:Contains 1 C1q domain.,similarity:Contains 1 collagen-like domain.,subunit:C1 is a calcium-dependent trimolecular complex of C1q, R and S in the molar ration of 1:2:2. C1q subcomponent is composed of nine subunits, six of which are disulfide-linked dimers of the A and B chains, and three of which are disulfide-linked dimers of the C chain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
