产品名称
CCDC8 Rabbit Polyclonal Antibody
蛋白名称
Coiled-coil domain-containing protein 8
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9H0W5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9H0W5/entry
Mouse Swissprot No.
D3YZV8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/D3YZV8
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P62521
免疫原
Synthesized peptide derived from part region of human protein
特异性
CCDC8 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a cofactor required for p53-mediated apoptosis following DNA damage, and may also play a role in growth through interactions with the cytoskeletal adaptor protein obscurin-like 1. Mutations in this gene are a cause of 3M syndrome-3 (3M3). [provided by RefSeq, Dec 2011],
组织表达
Widely expressed with low levels in spleen, skeletal muscle, small intestine, kidney and liver.
细胞定位
Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome .
功能
PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
