产品名称
RIF1 Rabbit Polyclonal Antibody
蛋白名称
Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/55183
Human Swissprot No.
Q5UIP0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q5UIP0/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/51869
Mouse Swissprot No.
Q6PR54
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6PR54
Rat Gene Link
https://www.uniprot.org/uniprot/51869
免疫原
Synthesized peptide derived from human RIF1 AA range: 1428-1478
特异性
This antibody detects endogenous levels of human RIF1
宿主
Polyclonal, Rabbit,IgG
组织表达
Highly expressed in testis.
细胞定位
Nucleus . Chromosome . Chromosome, telomere . Cytoplasm, cytoskeleton, spindle . Following interaction with TP53BP1, recruited to sites of DNA damage, such as DSBs (By similarity). Exhibits ATM- and TP53BP1-dependent localization to uncapped or aberrant telomeres and to DNA double strand breaks (DSBs) (PubMed:15342490). Does not associate with normal telomere structures (PubMed:15342490, PubMed:15583028). Localizes to microtubules of the midzone of the mitotic spindle during anaphase, and to condensed chromosomes in telophase (PubMed:15583028). .
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
