产品名称
MYCPP Rabbit Polyclonal Antibody
蛋白名称
C-myc promoter-binding protein (DENN domain-containing protein 4A)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q7Z401
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q7Z401/entry
免疫原
Synthesized peptide derived from part region of human protein
特异性
MYCPP Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a DENN domain-containing protein that may function as a guanine nucleotide exchange factor that specifically activates ras-related protein Rab-10. This protein also contains a interferon stimulated response element-binding domain and may be involved in regulating the v-myc avian myelocytomatosis viral (MYC) oncogene. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8. [provided by RefSeq, Mar 2016],
组织表达
Expressed ubiquitously. Highest expression in bone marrow, medium in peripheral blood lymphocytes and lowest in spleen. In brain, breast, and prostate, higher expression was seen in normal cells than in tumor cells. Expression is regulated in a growth- and cell cycle-dependent manner.
功能
developmental stage:Highly expressed in fetal liver.,function:Binds to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter.,induction:Induced by serum in low-passage fibroblasts.,similarity:Contains 1 dDENN domain.,similarity:Contains 1 DENN domain.,similarity:Contains 1 uDENN domain.,similarity:Contains 2 PPR (pentatricopeptide) repeats.,tissue specificity:Expressed ubiquitously. Highest expression in bone marrow, medium in peripheral blood lymphocytes and lowest in spleen. In brain, breast, and prostate, higher expression was seen in normal cells than in tumor cells. Expression is regulated in a growth- and cell cycle-dependent manner.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
