产品名称
CLD9 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O95484
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O95484/entry
Mouse Swissprot No.
Q9Z0S7
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9Z0S7
免疫原
Synthesized peptide derived from part region of human protein
特异性
CLD9 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein is one of the entry cofactors for hepatitis C virus. Mouse studies revealed that this gene is required for the preservation of sensory cells in the hearing organ and the gene deficiency is associated with deafness. [provided by RefSeq, Jun 2010],
组织表达
Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines.
细胞定位
Cell junction, tight junction. Cell membrane ; Multi-pass membrane protein .
信号通路
Cell adhesion molecules (CAMs);Tight junction;Leukocyte transendothelial migration;
功能
function:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.,similarity:Belongs to the claudin family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
