产品名称
LAT1 Rabbit Polyclonal Antibody
基因名称
SLC7A5 CD98LC LAT1 MPE16
蛋白名称
Large neutral amino acids transporter small subunit 1 (4F2 light chain) (4F2 LC) (4F2LC) (CD98 light chain) (Integral membrane protein E16) (L-type amino acid transporter 1) (hLAT1) (Solute carrier family 7 member 5) (y+ system cationic amino acid transporter)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/8140
Human Swissprot No.
Q01650
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q01650/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/20539
Mouse Swissprot No.
Q9Z127
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Z127
Rat Gene Link
https://www.uniprot.org/uniprot/20539
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q63016
免疫原
Synthesized peptide derived from human LAT1 AA range: 145-195
特异性
This antibody detects endogenous levels of human LAT1
宿主
Polyclonal, Rabbit,IgG
组织表达
Detected in placenta, in the syncytiotrophoblast layer (at protein level) (PubMed:11389679). Expressed abundantly in adult lung, liver, brain, skeletal muscle, placenta, bone marrow, testis, resting lymphocytes and monocytes, and in fetal liver. Weaker expression in thymus, cornea, retina, peripheral leukocytes, spleen, kidney, colon and lymph node. During gestation, expression in the placenta was significantly stronger at full-term than at the mid-trimester stage. Also expressed in all human tumor cell lines tested and in the astrocytic process of primary astrocytic gliomas. Expressed in retinal endothelial cells and in the intestinal epithelial cell line Caco-2.
细胞定位
Apical cell membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein . Located to the plasma membrane by SLC3A2/4F2hc (PubMed:9751058). Localized to the apical membrane of placental syncytiotrophoblastic cells (PubMed:11742812). Recruited to lysosomes by LAPTM4B (PubMed:25998567). Expressed in both luminal and abluminal membranes of brain capillary endothelial cells (By similarity). .
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
