产品名称
MYO1C Rabbit Polyclonal Antibody
蛋白名称
Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/4641
Human Swissprot No.
O00159
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O00159/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/17913
Mouse Swissprot No.
Q9WTI7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9WTI7
Rat Gene Link
https://www.uniprot.org/uniprot/17913
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q63355
免疫原
Synthesized peptide derived from human MYO1C AA range: 700-750
特异性
This antibody detects endogenous levels of human MYO1C
宿主
Polyclonal, Rabbit,IgG
细胞定位
[Isoform 1]: Cytoplasm . Nucleus . Colocalizes with RNA polymerase II. Absent from nucleoli and does not colocalize with RNA polymerase I. Translocates to nuclear speckles upon exposure to inhibitors of RNA polymerase II transcription.; [Isoform 2]: Cytoplasm. Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, stereocilium membrane . Cell projection, ruffle . Cytoplasmic vesicle . Colocalizes with CABP1 and CIB1 at cell margin, membrane ruffles and punctate regions on the cell membrane. Colocalizes in adipocytes with GLUT4 at actin-based membranes. Colocalizes with GLUT4 at insulin-induced ruffles at the cell membrane. Localizes transiently at cell membrane to region known to be enriched in PIP2. Activation of phospholipase C results in its redistribution to the cytoplasm (By similarity). .; [Isoform 3]: Nucleus, nucleoplasm. Nucleus, nucleolus. Nucleus, nuclear pore complex. Colocalizes with RNA polymerase II in the nucleus. Colocalizes with RNA polymerase I in nucleoli (By similarity). In the nucleolus, is localized predominantly in dense fibrillar component (DFC) and in granular component (GC). Accumulates strongly in DFC and GC during activation of transcription. Colocalizes with transcription sites. Colocalizes in the granular cortex at the periphery of the nucleolus with RPS6. Colocalizes in nucleoplasm with RPS6 and actin that are in contact with RNP particles. Colocalizes with RPS6 at the nuclear pore level. .
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
