产品名称
CNTFR Rabbit Polyclonal Antibody
蛋白名称
Ciliary neurotrophic factor receptor subunit alpha (CNTF receptor subunit alpha) (CNTFR-alpha)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P26992
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P26992/entry
Mouse Swissprot No.
O88507
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O88507
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q08406
免疫原
Synthesized peptide derived from part region of human protein
特异性
CNTFR Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011],
组织表达
Nervous system and skeletal muscle.
细胞定位
Cell membrane; Lipid-anchor, GPI-anchor.
信号通路
Cytokine-cytokine receptor interaction;Jak_STAT;
功能
domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:Binds to CNTF. The alpha chain provides the receptor specificity.,similarity:Belongs to the type I cytokine receptor family. Type 3 subfamily.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 2 fibronectin type-III domains.,subunit:Heterotrimer of the alpha chain, LIFR and IL6ST.,tissue specificity:Nervous system and skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
