产品名称
VMAT1 Rabbit Polyclonal Antibody
蛋白名称
Chromaffin granule amine transporter (Solute carrier family 18 member 1) (Vesicular amine transporter 1) (VAT1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P54219
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P54219/entry
Mouse Swissprot No.
Q8R090
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8R090
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q01818
免疫原
Synthesized peptide derived from part region of human protein
特异性
VMAT1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A2 (MIM 193001).[supplied by OMIM, Mar 2008],
组织表达
Highly expressed in chromaffin cells of the adrenal medulla (at protein level). Detected in peripheral sympathetic ganglia (at protein level). Found in some paracrine cells in stomach and duodenum (at protein level).
细胞定位
[Isoform 1]: Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein .; [Isoform 2]: Endoplasmic reticulum membrane ; Multi-pass membrane protein .
信号通路
Parkinson's disease;
功能
function:Involved in the vesicular transport of biogenic amines.,similarity:Belongs to the major facilitator superfamily. Vesicular transporter family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
