产品名称
BYST Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/705
Human Swissprot No.
Q13895
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q13895/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/53414
Mouse Swissprot No.
O54825
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O54825
Rat Gene Link
https://www.uniprot.org/uniprot/359727
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q80WL2
免疫原
Synthesized peptide derived from human BYST AA range: 127-177
特异性
This antibody detects endogenous levels of BYST at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
Bystin is expressed as a 2-kb major transcript and a 3.6-kb minor transcript in SNG-M cells and in human trophoblastic teratocarcinoma HT-H cells. Protein binding assays determined that bystin binds directly to trophinin and tastin, and that binding is enhanced when cytokeratins 8 and 18 are present. Immunocytochemistry of HT-H cells showed that bystin colocalizes with trophinin, tastin, and the cytokeratins, suggesting that these molecules form a complex in trophectoderm cells at the time of implantation. Using immunohistochemistry it was determined that trophinin and bystin are found in the placenta from the sixth week of pregnancy. Both proteins were localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the levels of trophinin, tastin, and bystin decreased and then disappeared from placental villi. [provided by RefSeq, Jul 2008],
组织表达
Found in the placenta from the sixth week of pregnancy. Was localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the level decreased and then disappeared from placental villi.
细胞定位
Cytoplasm . Nucleus, nucleolus . Associated with 40S ribosomal subunits.
功能
function:Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos.,miscellaneous:HeLa cells lacking BYSL show a delay in the processing of the 18S rRNA component of the 40S ribosomal subunit. HT-H cells lacking BYSL show trophinin-independent signaling through ERBB4.,similarity:Belongs to the bystin family.,subcellular location:Associated with 40S ribosomal subunits.,subunit:Binds trophinin, tastin and cytokeratins.,tissue specificity:Found in the placenta from the sixth week of pregnancy. Was localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the level decreased and then disappeared from placental villi.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
