产品名称
CLCKB Rabbit Polyclonal Antibody
蛋白名称
Chloride channel protein ClC-Kb (Chloride channel Kb) (ClC-K2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P51801
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P51801/entry
Mouse Swissprot No.
Q9WUB6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9WUB6
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P51802
免疫原
Synthesized peptide derived from part region of human protein
特异性
CLCKB Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the family of voltage-gated chloride channels. Chloride channels have several functions, including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. This gene is expressed predominantly in the kidney and may be important for renal salt reabsorption. Mutations in this gene are associated with autosomal recessive Bartter syndrome type 3 (BS3). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009],
组织表达
Expressed predominantly in the kidney.
细胞定位
Cell membrane; Multi-pass membrane protein.
功能
disease:Defects in CLCNKB are the cause of Bartter syndrome type 3 (BS3) [MIM:607364]; also known as classic Bartter syndrome. It is an autosomal recessive form of often severe intravascular volume depletion due to renal salt-wasting associated with low blood pressure, hypokalemic alkalosis, hypercalciuria, and normal serum magnesium levels.,function:Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms.,miscellaneous:Compared with CLCNKA/BSND, CLCNKB/BSND is more sensitive to pH and less responsive to Ca(2+).,similarity:Belongs to the chloride channel (TC 2.A.49) family.,similarity:Contains 2 CBS domains.,subunit:Interacts with BSND. Forms heteromers with BSND in the thick ascending limb of Henle and more distal segments.,tissue specificity:Expressed predominantly in the kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
