产品名称
CERU Rabbit Polyclonal Antibody
蛋白名称
Ceruloplasmin (EC 1.16.3.1) (Ferroxidase)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P00450
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P00450/entry
Mouse Swissprot No.
Q61147
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q61147
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P13635
免疫原
Synthesized peptide derived from part region of human protein
特异性
CERU Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012],
组织表达
Expressed by the liver and secreted in plasma.
细胞定位
Secreted. Colocalizes with GCP1 in secretory intracellular compartments. .
信号通路
Porphyrin and chlorophyll metabolism;
功能
catalytic activity:4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O.,cofactor:Binds 6 copper ions per monomer.,disease:Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2.,disease:Defects in CP are the cause of aceruloplasminemia (ACERULOP) [MIM:604290]. It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances.,function:Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane.,online information:Ceruloplasmin entry,similarity:Belongs to the multicopper oxidase family.,similarity:Contains 3 F5/8 type A domains.,similarity:Contains 6 plastocyanin-like domains.,tissue specificity:Expressed by the liver and secreted in plasma.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
