产品名称
CSPP1 Rabbit Polyclonal Antibody
蛋白名称
Centrosome and spindle pole-associated protein 1
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q1MSJ5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q1MSJ5/entry
Mouse Swissprot No.
B2RX88
Mouse Swissprot Link
http://www.uniprot.org/uniprot/B2RX88
免疫原
Synthesized peptide derived from part region of human protein
特异性
CSPP1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
centrosome and spindle pole associated protein 1(CSPP1) Homo sapiens This gene encodes a centrosome and spindle pole associated protein. The encoded protein plays a role in cell-cycle progression and spindle organization, regulates cytokinesis, interacts with Nephrocystin 8 and is required for cilia formation. Mutations in this gene result in primary cilia abnormalities and classical Joubert syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014],
组织表达
Expressed in adult and fetal brain with enrichment in the cerebellum. Detected in testis.
细胞定位
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole . Associated with mitotic spindles.
功能
developmental stage:Expression of isoform 1 increases throughout the cell cycle and peaks in G2/M phase. Expression of isoform 2 is highest in G1 phase and decreases thereafter.,function:May play a role in cell-cycle-dependent microtubule organization.,PTM:Phosphorylated. Phosphorylation increases in colcemide-treated cells.,subcellular location:Associated with mitotic spindles.,tissue specificity:Detected in testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
