产品名称
EXOC6 Rabbit Polyclonal Antibody
基因名称
EXOC6 SEC15A SEC15L SEC15L1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/54536
Human Swissprot No.
Q8TAG9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8TAG9/entry
Mouse Swissprot No.
Q8R313
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R313
Rat Gene Link
https://www.uniprot.org/uniprot/50556
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O54923
免疫原
Synthesized peptide derived from human EXOC6 AA range: 610-660
特异性
This antibody detects endogenous levels of EXOC6 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is highly similar to the Saccharomyces cerevisiae SEC15 gene product, which is essential for vesicular traffic from the Golgi apparatus to the cell surface in yeast. It is one of the components of a multiprotein complex required for exocytosis. The 5' portion of this gene and two neighboring cytochrome p450 genes are included in a deletion that results in an autosomal-dominant form of nonsyndromic optic nerve aplasia (ONA). Alternative splicing and the use of alternative promoters results in multiple transcript variants. A paralogous gene encoding a similar protein is present on chromosome 2. [provided by RefSeq, Jan 2016],
细胞定位
Cytoplasm . Cytoplasm, perinuclear region . Cell projection, growth cone . Midbody, Midbody ring . Perinuclear in undifferentiated cells. Redistributes to growing neurites and growth cones during neuronal differentiation. Colocalizes with CNTRL/centriolin at the midbody ring (PubMed:16213214). .
功能
function:Component of the exocyst complex involved in the docking of exocystic vesicles with fusion sites on the plasma membrane.,similarity:Belongs to the SEC15 family.,subunit:The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with CEP110.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
