产品名称
REST Rabbit Polyclonal Antibody
蛋白名称
RE1-silencing transcription factor (Neural-restrictive silencer factor) (X2 box repressor)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/5978
Human Swissprot No.
Q13127
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q13127/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/19712
Mouse Swissprot No.
Q8VIG1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VIG1
Rat Gene Link
https://www.uniprot.org/uniprot/19712
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O54963
免疫原
Synthesized peptide derived from human REST AA range: 593-643
特异性
This antibody detects endogenous levels of human REST
宿主
Polyclonal, Rabbit,IgG
组织表达
Expressed in neurons of the prefrontal cortex, in hippocampal pyramidal neurons, dentate gyrus granule neurons and cerebellar Purkinje and granule neurons (at protein level) (PubMed:24670762). Expressed in dopaminergic neurons of the substantia nigra (at protein level) (PubMed:30684677). Expressed in neural progenitor cells (at protein level) (PubMed:21258371). In patients suffering from Alzheimer disease, frontotemporal dementia or dementia with Lewy bodies, decreased nuclear levels have been observed in neurons of the prefrontal cortex and the hippocampus, but not in neurons of the dentate gyrus and cerebellum (at protein level) (PubMed:24670762). In patients with Parkinson disease or dementia with Lewy bodies, decreased nuclear levels have been observed in dopaminergic neurons and in cortical neurons and localization to Lewy bodies and pale bodies was detected (at protein level) (PubMed:30684677). Expressed at higher levels in weakly invasive breast cancer cell lines and at lower levels in highly invasive breast cancer lines (at protein level) (PubMed:26053433). Ubiquitous (PubMed:8568247). Expressed at higher levels in the tissues of the lymphocytic compartment, including spleen, thymus, peripheral blood lymphocytes and ovary (PubMed:8568247).
细胞定位
Nucleus . Cytoplasm . Colocalizes with ZFP90 in the nucleus (By similarity). In response to hypoxia, there is a more pronounced increase in levels in the nucleus as compared to the cytoplasm (PubMed:27531581). In aging neurons, increased levels in the nucleus as compared to the cytoplasm (PubMed:24670762, PubMed:30684677). .; [Isoform 2]: Cytoplasm .; [Isoform 3]: Nucleus .; [Isoform 4]: Cytoplasm .
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
