产品名称
CTSR1 Rabbit Polyclonal Antibody
蛋白名称
Cation channel sperm-associated protein 1 (CatSper1) (hCatSper)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8NEC5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8NEC5/entry
Mouse Swissprot No.
Q91ZR5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q91ZR5
免疫原
Synthesized peptide derived from part region of human protein
特异性
CTSR1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
预测分子量
human:85kD, Mouse 65-70kD
宿主
Polyclonal, Rabbit,IgG
背景介绍
Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. [provided by RefSeq, Jul 2008],
细胞定位
Cell projection, cilium, flagellum membrane ; Multi-pass membrane protein . Specifically located in the principal piece of the sperm tail. .
功能
developmental stage:Expressed meiotically and poszt-meiotically.,function:Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization.,induction:Down-regulated in patients lacking sperm motility.,similarity:Belongs to the cation channel sperm-associated family.,subunit:Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 (Potential). Component of a complex, at least composed of CATSPER1, HSPA1B and CATSPERB. Interacts with CATSPER3 and CATSPER4 (By similarity). Interacts with Ca(v)3.3/CACNA1I, leading to suppress T-type calcium channel activity.,tissue specificity:Testis-specific. Specifically present in the principal piece of sperm tail (at protein level).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
