产品名称
CTND2 Rabbit Polyclonal Antibody
蛋白名称
Catenin delta-2 (Delta-catenin) (GT24) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9UQB3
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UQB3/entry
Mouse Swissprot No.
O35927
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O35927
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941O35116
免疫原
Synthesized peptide derived from part region of human protein
特异性
CTND2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
catenin delta 2(CTNND2) Homo sapiens This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013],
组织表达
Expressed in brain; highest expression is observed in fetal brain (PubMed:25807484).
细胞定位
Nucleus . Cell junction, adherens junction . Cell projection, dendrite . Perikaryon .
功能
alternative products:Additional isoforms seem to exist,function:Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules.,PTM:O-glycosylated.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the beta-catenin family.,similarity:Contains 9 ARM repeats.,subunit:Binds to E-cadherin at a juxtamembrane site within the cytoplasmic domain. Interacts with PDZD2. Interacts with ZBTB33 (By similarity). Binds to PSEN1. Interacts with RGNEF.,tissue specificity:Predominantly expressed in brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
