产品名称
CBPA6 Rabbit Polyclonal Antibody
蛋白名称
Carboxypeptidase A6 (EC 3.4.17.1) (Carboxypeptidase B)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8N4T0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8N4T0/entry
Mouse Swissprot No.
Q5U901
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q5U901
免疫原
Synthesized peptide derived from part region of human protein
特异性
CBPA6 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The gene encodes a member of the peptidase M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature enzyme, which catalyzes the release of large hydrophobic C-terminal amino acids. This enzyme has functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Mutations in this gene may be linked to epilepsy and febrile seizures, and a translocation t(6;8)(q26;q13) involving this gene has been associated with Duane retraction syndrome. [provided by RefSeq, May 2016],
组织表达
Expressed in the hippocampus, nucleus raphe, and cortex.
细胞定位
Secreted, extracellular space, extracellular matrix .
功能
catalytic activity:Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.,cofactor:Binds 1 zinc ion per subunit.,disease:A chromosomal aberration disrupting CPA6 was found in a patient with Duane retraction syndrome (DURS) [MIM:126800]. Translocation t(6;8)(q26;q13).,similarity:Belongs to the peptidase M14 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
