产品名称
CBPA4 Rabbit Polyclonal Antibody
基因名称
CPA4 CPA3 UNQ694/PRO1339
蛋白名称
Carboxypeptidase A4 (EC 3.4.17.-) (Carboxypeptidase A3)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9UI42
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UI42/entry
Mouse Swissprot No.
Q6P8K8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q6P8K8
免疫原
Synthesized peptide derived from part region of human protein
特异性
CBPA4 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate cancer aggressiveness. [provided by RefSeq, Jul 2008],
组织表达
Fetal expression in the adrenal gland, brain, heart, intestine, kidney, liver and lung. Except for fetal brain that shows no imprinting, expression was found preferentially from the maternal allele.
功能
cofactor:Binds 1 zinc ion per subunit.,function:Metalloprotease that could be involved in the histone hyperacetylation pathway.,induction:Up-regulated by inhibitors of histone dacetylation.,similarity:Belongs to the peptidase M14 family.,subunit:Interacts with LXN.,tissue specificity:Fetal expression in the adrenal gland, brain, heart, intestine, kidney, liver and lung. Except for fetal brain that shows no imprinting, expression was found preferentially from the maternal allele.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
