产品名称
CTND2 Rabbit Polyclonal Antibody
蛋白名称
Catenin delta-2 (Delta-catenin) (GT24) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9UQB3
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UQB3/entry
Mouse Swissprot No.
O35927
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O35927
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941O35116
免疫原
Synthesized peptide derived from part region of human protein
特异性
CTND2 Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
catenin delta 2(CTNND2) Homo sapiens This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013],
组织表达
Expressed in brain; highest expression is observed in fetal brain (PubMed:25807484).
细胞定位
Nucleus . Cell junction, adherens junction . Cell projection, dendrite . Perikaryon .
功能
alternative products:Additional isoforms seem to exist,function:Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules.,PTM:O-glycosylated.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the beta-catenin family.,similarity:Contains 9 ARM repeats.,subunit:Binds to E-cadherin at a juxtamembrane site within the cytoplasmic domain. Interacts with PDZD2. Interacts with ZBTB33 (By similarity). Binds to PSEN1. Interacts with RGNEF.,tissue specificity:Predominantly expressed in brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
