产品名称
CHSTE Rabbit Polyclonal Antibody
基因名称
CHST14 D4ST1 UNQ1925/PRO4400
蛋白名称
Carbohydrate sulfotransferase 14 (EC 2.8.2.35) (Dermatan 4-sulfotransferase 1) (D4ST-1) (hD4ST1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8NCH0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8NCH0/entry
Mouse Swissprot No.
Q80V53
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q80V53
免疫原
Synthesized peptide derived from part region of human protein
特异性
CHSTE Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the HNK-1 family of sulfotransferases. The encoded protein transfers sulfate to the C-4 hydroxyl of N-acetylgalactosamine residues in dermatan sulfate. Mutations in this gene have been associated with adducted thumb-clubfoot syndrome.[provided by RefSeq, Mar 2010],
组织表达
Widely expressed. Expressed at high level in pituitary gland, placenta, uterus and thyroid.
细胞定位
Golgi apparatus membrane ; Single-pass type II membrane protein .
信号通路
Chondroitin sulfate biosynthesis;
功能
function:Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA.,similarity:Belongs to the sulfotransferase 2 family.,tissue specificity:Widely expressed. Expressed at high level in pituitary gland, placenta, uterus and thyroid.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
