产品名称
KCNK2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/3776
Human Swissprot No.
O95069
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O95069/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/16526
Mouse Swissprot No.
P97438
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P97438
免疫原
Synthesized peptide derived from human KCNK2 AA range: 219-269
特异性
This antibody detects endogenous levels of KCNK2 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
组织表达
Isoform 4 is detected in kidney, adrenal gland and brain where it is preferentially expressed in the amygdala but not found in thalamus, hypothalamus, hippocampus or substantia nigra.
细胞定位
[Isoform 1]: Cell membrane ; Multi-pass membrane protein .; [Isoform 2]: Cell membrane ; Multi-pass membrane protein .; [Isoform 4]: Endoplasmic reticulum membrane ; Multi-pass membrane protein .
功能
function:Outward rectifying potassium channel.,miscellaneous:Activated by volatile general anesthetics such as chloroform, halothane and isoflurane.,similarity:Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.,subunit:Homodimer .,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
