产品名称
SP110 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/3431
Human Swissprot No.
Q9HB58
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9HB58/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/109032
Mouse Swissprot No.
Q8BVK9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BVK9
Rat Gene Link
https://www.uniprot.org/uniprot/301570
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q3KRF1
免疫原
Synthesized peptide derived from human SP110 AA range: 453-503
特异性
This antibody detects endogenous levels of SP110 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Jul 2008],
组织表达
Highly expressed in peripheral blood leukocytes and spleen. Detected at intermediate levels in thymus, prostate, testis, ovary, small intestine and colon, and at low levels in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
细胞定位
Nucleus . Found in the nuclear body.
功能
disease:Defects in SP110 are the cause of hepatic venoocclusive disease with immunodeficiency (VODI) [MIM:235550]. VODI is an autosomal recessive primary immunodeficiency associated with hepatic vascular occlusion and fibrosis. The immunodeficiency is characterized by severe hypogammaglobulinemia, combined T and B cell immunodeficiency, absent lymph node germinal centers, and absent tissue plasma cells.,function:Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE).,induction:By interferon gamma and by all-trans retinoic acid.,online information:SP110 mutation db,PTM:Phosphorylated (isoform 2).,similarity:Contains 1 bromo domain.,similarity:Contains 1 HSR domain.,similarity:Contains 1 PHD-type zinc finger.,similarity:Contains 1 SAND domain.,subcellular location:Found in the nuclear body.,subunit:Isoform 3 interacts with HCV core protein.,tissue specificity:Highly expressed in peripheral blood leukocytes and spleen. Detected at intermediate levels in thymus, prostate, testis, ovary, small intestine and colon, and at low levels in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
