产品名称
CBPD Rabbit Polyclonal Antibody
蛋白名称
Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) (gp180)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O75976
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O75976/entry
Mouse Swissprot No.
O89001
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O89001
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q9JHW1
免疫原
Synthesized peptide derived from part region of human protein
特异性
CBPD Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
carboxypeptidase D(CPD) Homo sapiens The metallocarboxypeptidase family of enzymes is divided into 2 subfamilies based on sequence similarities. The pancreatic carboxypeptidase-like and the regulatory B-type carboxypeptidase subfamilies. Carboxypeptidase D has been identified as a regulatory B-type carboxypeptidase. CPD is a homolog of duck gp180, a hepatitis B virus-binding protein. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Jul 2008],
组织表达
Highly expressed in placenta, pancreas and hepatoma cells. Lower levels found in skeletal muscle, heart and colon carcinoma and melanoma cell lines.
细胞定位
Cell membrane ; Single-pass type I membrane protein .
功能
catalytic activity:Releases C-terminal Arg and Lys from polypeptides.,cofactor:Binds 2 zinc ions per subunit.,domain:There are 3 carboxypeptidase-like domains. Only the first two domains seem to have kept a catalytic activity.,similarity:Belongs to the peptidase M14 family.,tissue specificity:Highly expressed in placenta, pancreas and hepatoma cells. Lower levels found in skeletal muscle, heart and colon carcinoma and melanoma cell lines.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
