产品名称
CALR3 Rabbit Polyclonal Antibody
蛋白名称
Calreticulin-3 (Calreticulin-2) (Calsperin)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q96L12
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96L12/entry
Mouse Swissprot No.
Q9D9Q6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9D9Q6
免疫原
Synthesized peptide derived from part region of human protein
特异性
CALR3 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the calreticulin family, members of which are calcium-binding chaperones localized mainly in the endoplasmic reticulum. This protein is also localized to the endoplasmic reticulum lumen, however, its capacity for calcium-binding may be absent or much lower than other family members. This gene is specifically expressed in the testis, and may be required for sperm fertility. Mutation in this gene has been associated with familial hypertrophic cardiomyopathy. [provided by RefSeq, Dec 2011],
细胞定位
Endoplasmic reticulum lumen .
功能
domain:Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity.,domain:The interaction with glycans occurs through a binding site in the globular lectin domain.,domain:The zinc binding sites are localized to the N-domain.,function:Molecular calcium binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER.,similarity:Belongs to the calreticulin family.,subunit:Component of an EIF2 complex at least composed of CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5.,tissue specificity:Testis specific.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
