BD-PN0539

CAN6 Rabbit Polyclonal Antibody

常规抗体

CAPN6 CALPM CANPX

Calpain-6 (Calpain-like protease X-linked) (Calpamodulin) (CalpM)

WB

Human,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

827

Q9Y6Q1

https://www.uniprot.org/uniprotkb/Q9Y6Q1/entry

O35646

http://www.uniprot.org/uniprot/O35646

O88501

http://www.uniprot.org/uniprot/O54941O88501

Synthesized peptide derived from part region of human protein

CAN6 Polyclonal Antibody detects endogenous levels of protein.

WB 1:500-2000 ELISA 1:5000-20000

70kD

-20°C/1 year

Polyclonal, Rabbit,IgG

Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis. [provided by RefSeq, Nov 2009],

Expressed only in placenta.

Cytoplasm, perinuclear region . Cytoplasm, cytoskeleton, spindle . During mitose associated with the mitotic spindle. At telophase colocalized to the midbody spindle.

function:Not known; does not seem to have protease activity as it has lost the active site residues.,similarity:Belongs to the peptidase C2 family.,similarity:Contains 1 C2 domain.,similarity:Contains 1 calpain catalytic domain.,tissue specificity:Expressed only in placenta.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.