产品名称
Ub (Acetyl Lys6) Rabbit Polyclonal Antibody
别名
Ubiquitin-60S ribosomal protein L40 (CEP52;Ubiquitin A-52 residue ribosomal protein fusion product 1) [Cleaved into: Ubiquitin; 60S ribosomal protein L40]
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/7311
Human Swissprot No.
P62987/P62979/P0CG47/P0CG48
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P62987/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/22186
Mouse Swissprot No.
P62984
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P62984
Rat Gene Link
https://www.uniprot.org/uniprot/64156
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P62986
免疫原
Synthesized peptide derived from human Ub (Acetyl Lys6)
特异性
This antibody detects endogenous levels of Human,Mouse,Rat Ub (Acetyl Lys6)
稀释度
WB 1:1000-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein L40 at the C terminus, a C-terminal extension protein (CEP). Multiple processed pseudogenes derived from this gene are present in the genome. [provided by RefSeq, Jul 2008],
细胞定位
[Ubiquitin]: Cytoplasm . Nucleus .; [60S ribosomal protein L40]: Cytoplasm .
功能
function:Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous functions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair.,miscellaneous:This ribosomal protein is synthesized as a C-terminal extension protein (CEP) of ubiquitin.,miscellaneous:Ubiquitin is synthesized as a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains. In some species there is a final amino-acid after the last repeat, here in human a Val. Some ubiquitin genes contain a single copy of ubiquitin fused to a ribosomal protein (either L40 or S27a).,PTM:Several types of polymeric chains can be formed, depending on the lysine used for the assembly.,similarity:Belongs to the ribosomal protein L40e family.,similarity:Belongs to the ribosomal protein S27Ae family.,similarity:Belongs to the ubiquitin family.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
