产品名称
Stat2 (Acetyl Lys384) Rabbit Polyclonal Antibody
别名
Signal transducer and activator of transcription 2 (p113)
蛋白名称
Stat2 (Acetyl Lys384)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/6773
Human Swissprot No.
P52630
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P52630/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/0
Mouse Swissprot No.
Q9WVL2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9WVL2
免疫原
Synthesized peptide derived from human Stat2 (Acetyl Lys384)
特异性
This antibody detects endogenous levels of Human,Rat Stat2 (Acetyl Lys384)
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
function:Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.,PTM:Tyrosine phosphorylated in response to IFN-alpha.,similarity:Belongs to the transcription factor STAT family.,similarity:Contains 1 SH2 domain.,subcellular location:Translocated into the nucleus upon activation by IFN-alpha/beta.,subunit:Interacts with ISGF3G/IRF-9 in the cytoplasm. Heterodimer with STAT1 upon IFN-alpha/beta induced phosphorylation. Interacts with CRSP2 and CRSP6. Interacts with Simian virus 5 protein V and rabies virus phosphoprotein.,
细胞定位
Cytoplasm . Nucleus . Translocated into the nucleus upon activation by IFN-alpha/beta. .
功能
transcription,?regulation of transcription, DNA-dependent,?regulation of transcription from RNA polymerase II promoter,intracellular signaling cascade,?protein kinase cascade,?JAK-STAT cascade,?response to virus,?regulation of transcription,?regulation of RNA metabolic process,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
