产品名称
DNA pol β (Acetyl Lys72) Rabbit Polyclonal Antibody
别名
DNA polymerase beta (EC 2.7.7.7;EC 4.2.99.-)
蛋白名称
DNA pol β (Acetyl Lys72)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/5423
Human Swissprot No.
P06746
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P06746/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/18970
Mouse Swissprot No.
Q8K409
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K409
Rat Gene Link
https://www.uniprot.org/uniprot/29240
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P06766
免疫原
Synthesized peptide derived from human DNA pol β (Acetyl Lys72)
特异性
This antibody detects endogenous levels of Human,Mouse,Rat DNA pol β (Acetyl Lys72)
稀释度
WB 1:1000-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
catalytic activity:Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).,cofactor:Binds 2 magnesium ions per subunit.,domain:Residues 239-252 form a flexible loop which appears to affect the polymerase fidelity.,function:Repair polymerase. Conducts "gap-filling" DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.,PTM:Methylation by PRMT6 stimulates the polymerase activity by enhancing DNA binding and processivity.,similarity:Belongs to the DNA polymerase type-X family.,subunit:Monomer.,
细胞定位
Nucleus. Cytoplasm. Cytoplasmic in normal conditions. Translocates to the nucleus following DNA damage.
功能
DNA metabolic process,?DNA replication,?DNA-dependent DNA replication,?DNA repair,?base-excision repair,?pyrimidine dimer repair,?anti-apoptosis,?response to DNA damage stimulus,?cell death,?regulation of cell death,?death,?cellular response to stress,?regulation of apoptosis,?negative regulation of apoptosis,?regulation of programmed cell death,negative regulation of programmed cell death,?negative regulation of cell death,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
