产品名称
CMTA1 Rabbit Polyclonal Antibody
基因名称
CAMTA1 KIAA0833 MSTP023
蛋白名称
Calmodulin-binding transcription activator 1
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9Y6Y1
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y6Y1/entry
Mouse Swissprot No.
A2A891
Mouse Swissprot Link
http://www.uniprot.org/uniprot/A2A891
免疫原
Synthesized peptide derived from part region of human protein
特异性
CMTA1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
disease:Defects in CAMTA1 are detected in patients with oligodendroglioma and astrocytoma.,function:Transcriptional activator. May act as a tumor suppressor.,induction:Detected at low levels at interphase and in resting cells. Up-regulated during S-phase and mitosis. Levels decrease at the end of mitosis.,similarity:Belongs to the CAMTA family.,similarity:Contains 1 CG-1 DNA-binding domain.,similarity:Contains 1 IPT/TIG domain.,similarity:Contains 3 ANK repeats.,similarity:Contains 3 IQ domains.,subunit:May interact with calmodulin .,tissue specificity:Detected in whole brain, cerebellum, brain cortex, occipital lobe, frontal lobe, temporal lobe, putamen, heart and kidney. Detected in neuroblastic-type cultured neuroblastoma cells.,
组织表达
Normally expressed in non-neoplastic adult central nervous system tissues: detected in whole brain, cerebellum, brain cortex, occipital lobe, frontal lobe, temporal lobe, putamen. Expression levels are low in oligodendroglial tumors, and are reduced by half in oligodendroglioma and astrocytoma cases with 1p loss of heterozygosity. Detected in neuroblastic-type cultured neuroblastoma cells. Expressed in heart and kidney.
细胞定位
Nucleus . Cytoplasm .
功能
disease:Defects in CAMTA1 are detected in patients with oligodendroglioma and astrocytoma.,function:Transcriptional activator. May act as a tumor suppressor.,induction:Detected at low levels at interphase and in resting cells. Up-regulated during S-phase and mitosis. Levels decrease at the end of mitosis.,similarity:Belongs to the CAMTA family.,similarity:Contains 1 CG-1 DNA-binding domain.,similarity:Contains 1 IPT/TIG domain.,similarity:Contains 3 ANK repeats.,similarity:Contains 3 IQ domains.,subunit:May interact with calmodulin .,tissue specificity:Detected in whole brain, cerebellum, brain cortex, occipital lobe, frontal lobe, temporal lobe, putamen, heart and kidney. Detected in neuroblastic-type cultured neuroblastoma cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
