产品名称
MyoD (Acetyl Lys99/K102) Rabbit Polyclonal Antibody
别名
Myoblast determination protein 1 (Class C basic helix-loop-helix protein 1;bHLHc1;Myogenic factor 3;Myf-3)
基因名称
MYOD1 BHLHC1 MYF3 MYOD
蛋白名称
MyoD (Acetyl Lys99/K102)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/4654
Human Swissprot No.
P15172
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P15172/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/17927
Mouse Swissprot No.
P10085
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P10085
Rat Gene Link
https://www.uniprot.org/uniprot/337868
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q02346
免疫原
Synthesized peptide derived from human MyoD (Acetyl Lys99/K102)
特异性
This antibody detects endogenous levels of Human MyoD (Acetyl Lys99/K102)
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis. [provided by RefSeq, Jul 2008],
功能
function:Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Activates muscle-specific promoters. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins.,online information:MyoD entry,PTM:Acetylated by a complex containing EP300 and PCAF. The acetylation is essential to activate target genes. Conversely, its deacetylation by SIRT1 inhibits its function.,PTM:Ubiquitinated on the N-terminus; which is required for proteasomal degradation.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Seems to form active heterodimers with ITF-2. Interacts with SUV39H1.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
