背景介绍
developmental stage:Expression does not increase during promyelocyte differentiation.,disease:Individuals with systemic lupus erythematosus (SLE) and related disorders produce extremely large amounts of autoantibodies to p70 and p86. Existence of a major autoantigenic epitope or epitopes on the C-terminal 190 amino acids of p70 containing the leucine repeat. The majority of autoantibodies to p70 in most sera from patients with SLE seem to be reactive with this region.,function:Single stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by p70. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The Ku p70/p86 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The Ku p70/p86 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression.,induction:In osteoblasts, by FGF2.,PTM:Phosphorylation by PRKDC may enhance helicase activity. Phosphorylation of Ser-51 does not affect DNA repair.,similarity:Belongs to the ku70 family.,similarity:Contains 1 Ku domain.,similarity:Contains 1 SAP domain.,subunit:Heterodimer of a 70 kDa and a 80 kDa subunit. The dimer associates in a DNA-dependent manner with PRKDC to form the DNA-dependent protein kinase complex DNA-PK, and with the LIG4-XRCC4 complex. The dimer also associates with NARG1, and this complex binds to the osteocalcin promoter and activates osteocalcin expression. In addition, the 70 kDa subunit binds to the osteoblast-specific transcription factors MSX2, RUNX2 and DLX5. Interacts with ELF3. Interactis with XRCC6BP1.,
功能
telomere maintenance,?non-recombinational repair,?somatic diversification of immune receptors,?immune system development,?somatic diversification of immune receptors via germline recombination within a single locus,?DNA metabolic process,?DNA ligation,?DNA repair,?double-strand break repair,?double-strand break repair via nonhomologous end joining,?DNA recombination,?regulation of transcription, DNA-dependent,?regulation of transcription from RNA polymerase II promoter,?response to DNA damage stimulus,?response to radiation,?response to abiotic stimulus,?positive regulation of biosynthetic process,?response to ionizing radiation,?regulation of specific transcription from RNA polymerase II promoter,?positive regulation of specific transcription from RNA polymerase II promoter,?positive regulation of macromolecule biosynthetic process,?positive regulation of macromolecule metabolic process,?positive regulation of gene expression,?positive regulation of cell development,?DNA integration,?viral reproduction,?somatic cell DNA recombination,?provirus integration,?viral infectious cycle,?initiation of viral infection,?viral reproductive process,?lysogeny,?positive regulation of cellular biosynthetic process,?telomere organization,?regulation of gene-specific transcription,?V(D)J recombination,?cellular response to stress,?homeostatic process,?positive regulation of gene-specific transcription,?regulation of transcription,?positive regulation of cell differentiation,?positive regulation of transcription, DNA-dependent,?positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process,?positive regulation of transcription,?positive regulation of transcription from RNA polymerase II promoter,?regulation of neurogenesis,?positive regulation of neurogenesis,?positive regulation of developmental process,?positive regulation of nitrogen compound metabolic process,?regulation of RNA metabolic process,?positive regulation of RNA metabolic process,?chromosome organization,?regulation of nervous system development,anatomical structure homeostasis,?regulation of cell development,
