产品名称
CAPS2 Rabbit Polyclonal Antibody
基因名称
CADPS2 CAPS2 KIAA1591
蛋白名称
Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q86UW7
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q86UW7/entry
Mouse Swissprot No.
Q8BYR5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BYR5
免疫原
Synthesized peptide derived from part region of human protein
特异性
CAPS2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
calcium dependent secretion activator 2(CADPS2) Homo sapiens This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009],
组织表达
Widely expressed. Expressed in all adult and fetal tissues examined, with the strongest expression in kidney and pancreas. In brain, it is expressed at high levels in cerebellum, to a lesser degree in cerebral cortex, occipital pole, and frontal and temporal lobes. Only weakly expressed in medulla, spinal cord and putamen.
细胞定位
Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell junction, synapse. Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Probably localizes to different vesicles compared to CADPS. Enriched on vesicular structures in the parallel fiber terminal of granule cells that are distinct from synaptic vesicles.
功能
domain:The PH domain is essential for regulated exocytosis and binds phospholipids.,function:Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles.,PTM:Isoform 2 is phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Chimera.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Contains 1 C2 domain.,similarity:Contains 1 MHD1 (MUNC13 homology domain 1) domain.,similarity:Contains 1 PH domain.,subcellular location:Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Probably localizes to different vesicles compared to CADPS. Enriched on vesicular structures in the parallel fiber terminal of granule cells that are distinct from synaptic vesicles.,subunit:Homodimer (By similarity). Interacts with the dopamine receptor DRD2.,tissue specificity:Widely expressed. Expressed in all adult and fetal tissues examined, with the strongest expression in kidney and pancreas. In brain, it is expressed at high levels in cerebellum, to a lesser degree in cerebral cortex, occipital pole, and frontal and temporal lobes. Only weakly expressed in medulla, spinal cord and putamen.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
